Born Andrea Kay Pyle in Houston, TX, a six-month-old Pyle was given the fateful nickname of "Little Missi," which would stick to her throughout her childhood and to the present day. Pyle was infatuated with acting by the age of 13, and attended Germantown High School in Tennessee, one of the top three performing-arts high schools in the United States. While there, Pyle was tapped as a lead singer in several musical productions, though her eventual goal remained a career in television and film. After graduation from Germantown High, Pyle was accepted to the prestigious North Carolina School of the Arts and was cast as the female lead in a series of Shakespearean productions. During the summer, she crossed the Atlantic to attend the Oxford School of Drama in England, where she further honed her acting skills. By , Pyle had made her film debut in The Cottonwood, which followed a group of wannabe actors hoping to use their lottery winnings to score big in Hollywood.
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Pyle attended the North Carolina School of the Arts and graduated in Since then, Pyle has had a significant career in many films and television series. Pyle is also an occasional voice actress, and has voiced characters in one episode of series Family Guy and two episodes of American Dad! Pyle began a career as a singer when she met Shawnee Smith in while filming an ABC comedy pilot. Their debut album "It's OK to Be Happy" was recorded in Joshua Tree, California and was released under their own record label when they became business partners. Their first live performance was in Texas on January 18, and since then, the band performed in many other states, especially in West Virginia, until May 29, in California. In , the actresses officially disbanded before their second album was completed.
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